The Drennen-Scott House is a pre-Civil War Greek Revival house that survives in good condition on North 3rd Street, a few blocks from the Main Street commercial district. The house dates from the 1850s and is furnished with period pieces that reflect the appearance of a prosperous Arkansas River town household of the era. Guided tours cover the history of the building and the families who lived in it.
The museum is operated by the Crawford County Historical Society and is open on limited days — check hours before visiting. The house is the best surviving example of antebellum domestic architecture in Van Buren and gives a concrete sense of the town's position as an important commercial and administrative centre before the Civil War.