The L&N Train Depot at 189 10th Street is a restored 1890 Romanesque Revival building that served as Clarksville's main railroad station until passenger service ended in the 20th century. The brick building with its arched windows and decorative stonework is one of the more attractive pieces of railroad architecture in middle Tennessee.
The depot has been restored and now houses offices, but the exterior can be seen from the street and it is part of the downtown historic district walking circuit. The building is listed on the National Register of Historic Places. The surrounding area near the riverfront has some of the best surviving 19th-century commercial architecture in Clarksville.