Manzini is compact and most of the town centre can be covered on foot. The market area and cathedral are both within easy walking distance of the main kombi and bus ranks.
For longer distances within Eswatini, Manzini is the hub. Kombis (shared minibuses) depart from the main rank to virtually every part of the country — to Mbabane in the north (about 30 minutes), the Ezulwini Valley, Siteki, Big Bend, and the border crossings. They leave when full, which in practice means short waits during the day. Shared taxis to South African border posts (Matsamo, Mahamba, Oshoek) also run from the rank.
The King Mswati III International Airport at Sikhuphe is reached by taxi; there is no scheduled shuttle service.