Lodhran is accessible by train on the main Kotri-Attock line. Lodhran Junction station has services to Multan (about 80 km northeast, roughly one hour by train) and Bahawalpur to the south. Lahore is approximately five to six hours north by express train.
By road, Lodhran sits on a main highway connecting Multan and Bahawalpur. Buses and minivans run frequently between Multan and Lodhran throughout the day. The journey takes about 90 minutes by bus.
There is no airport in Lodhran; the nearest is Multan International Airport.