The collegiate church of Sant'Ambrogio is Varazze's principal monument, standing on the square of the same name in the historic centre. The church was built in 1535, incorporating an older Romanesque-Gothic campanile from the 14th century. The tower, with its three tiers of triple-arched windows, is the finest architectural element in town and gives the square its character.
The interior is Baroque with some earlier elements, including a polyptych altarpiece from the 15th century. The church is dedicated to Sant'Ambrogio (Saint Ambrose), the bishop of Milan who is one of the four original Doctors of the Church. Varazze was an important stopping point on medieval pilgrimage routes along the Ligurian coast, and the church's significance was greater then than its current modest profile suggests.