Comrat's main cathedral is a bright yellow Orthodox church with gold accents, built in 1820 and still the strongest visual landmark in the centre. It stands near the city's main square, so almost every walk through Comrat passes it sooner or later.
The church is not large by regional standards, but it gives the capital a clear centre. Step inside if it is open, then use the square around it to get your bearings before heading to the museums or winery.