Little River Canyon National Preserve is the principal reason to visit Fort Payne. The Little River runs along the top of Lookout Mountain before dropping into a canyon system of forested walls, sandstone cliffs, and boulder-strewn pools. The canyon rim drive — Canyon Rim Road — offers a series of pull-offs with overlooks down into the gorge, each one different. The views at sunset are particularly good.
DeSoto Falls, at the northern end of the preserve, drops 100 feet into a pool and is the most accessible waterfall. Further south, the river creates natural swimming holes in the canyon bottom that are popular in summer — access requires hiking down the canyon walls on maintained trails. The preserve is undeveloped enough to feel genuinely wild; wildlife includes white-tailed deer, wild turkeys, and occasional black bears. The visitor centre near the canyon rim has trail maps and information on current water conditions.