Page is on US Highway 89, about 270 kilometres north of Flagstaff, Arizona. There's no scheduled public transport; a rental car is essential. The drive from Flagstaff through the Navajo Nation is dramatic and worth doing in daylight. From Las Vegas, it's about 4.5 hours via US-93 and US-89; from Phoenix, about 4 hours.
Page Municipal Airport (PGA) has limited charter and commuter service but no regular commercial flights. The nearest major airports are Flagstaff Pulliam (FLG) and Phoenix Sky Harbor (PHX). If you're based in Las Vegas and want to see only Antelope Canyon and Horseshoe Bend, day trips and two-day tours are operated by several Las Vegas companies — a reasonable option if you have limited time.