Georgetown sits at the junction of US Route 9 and US Route 113 in central Sussex County. By car it is about 45 minutes south of Dover (the state capital), 90 minutes from Wilmington, and 30 minutes from Rehoboth Beach.
There is no Amtrak service to Georgetown. The DART First State bus system runs limited service between Georgetown and other Sussex County towns including Lewes and Rehoboth Beach, but a car is the practical choice for most visitors. Delaware Coastal Airport (GED), a general aviation field, is located a couple of miles east of the town centre.