Big Pine Key is at Mile Marker 30 to 33 on the Overseas Highway (US Route 1), roughly 33 miles northeast of Key West and about 100 miles southwest of Miami.
By car is the only practical option for most visitors. From Miami, take the Florida Turnpike south to Florida City and then US-1 through the Keys. The drive takes around two to two and a half hours without traffic, but weekends and holidays can add significant time in the Upper Keys around Key Largo and Islamorada. There is no practical public transport along the Keys — a car is essential for moving around once you arrive.
Key West International Airport is the closest commercial airport, about 33 miles southwest. It serves a limited number of direct routes from major US cities, primarily through American Airlines and Delta. Miami International Airport is the larger hub, offering connections worldwide, with rental cars available for the drive south.
The Key West Express ferry operates from Fort Myers Beach on the Gulf Coast of Florida to Key West, with seasonal service. Passengers can then rent a car in Key West and drive back up to Big Pine Key — an option that avoids the Miami traffic entirely.
Parking on the island is easy and free at most attractions, including the National Key Deer Refuge visitor area and the Blue Hole trailhead.