Ybor City sits just northeast of downtown Tampa, about 15 minutes by car. The simplest approach from elsewhere in Tampa Bay is to drive to one of the public lots on 5th or 6th Avenue and walk; parking is plentiful but fills up early on weekend nights.
The free TECO streetcar connects Ybor to downtown Tampa, the Channel District, and the cruise terminal. From Tampa International Airport, the ride is about twenty minutes by taxi or rideshare. There are no convenient train or long-distance bus connections to Ybor itself — use Tampa Union Station downtown and switch to the streetcar.