Lafayette is on Interstate 65, about 95 kilometres (60 miles) north of Indianapolis — roughly an hour's drive. Chicago is about 200 kilometres (125 miles) north on I-65. Amtrak's Cardinal and Hoosier State lines have historically served the city, though service has been intermittent; check current schedules before planning around it.
The nearest major airport is Indianapolis International (IND), about an hour south. No significant commercial air service operates into the local Purdue University Airport.