South Bend Regional Airport (SBN) receives direct flights from several major hubs including Chicago O'Hare, Atlanta, Charlotte, Dallas, and Detroit. It is a modest regional airport, so options are limited compared to Chicago; many visitors fly into O'Hare and drive the 90 miles east on the I-80/90 tollway.
Amtrak's Wolverine service stops at South Bend on its route between Chicago and Detroit/Pontiac, with multiple trains daily in each direction. The station is downtown, close to the river. Greyhound and Megabus connect South Bend to Chicago regularly. By car, South Bend sits on the Indiana Toll Road (I-80/I-90), making it easy to reach from Chicago, Cleveland, and Detroit.