By car. Holly sits right on I-75 at exit 101 (Grange Hall Road) and exit 102 (Holly Road). Detroit is 50 miles to the south, Flint 20 miles north, and Pontiac about 25 miles south-east. Most visitors arrive by car.
By air. Detroit Metropolitan (DTW), an hour to the south, is the nearest major airport. Flint Bishop (FNT) is closer, with limited domestic service.
By train. Amtrak's Blue Water service between Chicago and Port Huron stops in Flint and Pontiac, both within a half-hour drive of Holly. There is no passenger station in Holly itself any more, though the historic Holly Union Depot still stands downtown.