Fergus Falls sits on Interstate 94, exactly midway between the Twin Cities (about 200 km southeast) and Fargo, North Dakota (about 130 km west). It is the natural stopping point on the drive between the two cities.
Greyhound buses stop in Fergus Falls on the Minneapolis-Fargo route. The Amtrak Empire Builder passes through the region but the nearest station is in Detroit Lakes (30 miles north) or Staples (60 miles east). Flying into Minneapolis-Saint Paul International Airport and driving north is the most practical approach for visitors coming from further afield.