Southaven sits at the intersection of Interstates 55 and 69 just south of Memphis. Most visitors fly into Memphis International Airport (MEM), which is fifteen minutes north of Southaven and one of FedEx's main global hubs — flights from across the United States are easy to find.
The car is essential. Public transit is minimal and ride-share covers Southaven but is more expensive than in Memphis proper. From Nashville the drive south on I-40 and then I-269/I-55 takes about three and a half hours.