West Orange is about 12 miles west of Newark. The easiest public transport option is the NJ Transit bus from Newark Penn Station to the Edison lab area — check the NJ Transit website for current route numbers, as services have changed over the years. Newark itself is served by NJ Transit trains from New York Penn Station (about 20–30 minutes).
By car from New York City, take I-78 west or the Garden State Parkway south to the West Orange exits. Parking near the Edison lab is available on the street. If you plan to visit both the lab and Glenmont, note that Glenmont is in Llewellyn Park, about a mile from the main lab building — tours typically include transport between the two.