Oxford has no commercial airport or train service. The nearest airports are Cincinnati/Northern Kentucky International Airport (CVG), about 45 minutes south, and Dayton International Airport (DAY), about 40 minutes north. Both are served by major carriers.
By car, Oxford sits at the junction of US Route 27 and Ohio Route 73, easily reached from Interstate 75 via exits near Hamilton. From Cincinnati, take I-75 north to the Ross–Hamilton area and follow signs west on OH-129 or OH-73. From Dayton, take I-75 south.
There is no direct Greyhound or Megabus service to Oxford itself. The Oxford Transit system operates local bus routes connecting the university and town, but for getting to Oxford from elsewhere you will need a car or a ride from Cincinnati or Dayton.