Manzanita sits on US-101 about 90 miles west of Portland via US-26 to US-101 south — roughly two hours in normal traffic, longer on summer Friday afternoons when the highway backs up at Cannon Beach. There is no public transport to the town itself; a car is essentially required.
Portland International Airport (PDX) is the nearest major airport. From Portland, head west on US-26 (the Sunset Highway) over the Coast Range to Seaside, then south on US-101 to the Manzanita turnoff at Neahkahnie Mountain.