Issaquah sits at exits 15–18 of Interstate 90, about 16 miles east of downtown Seattle — 25–35 minutes off-peak, longer in commuter traffic.
By bus, King County Metro's 554 runs frequently between Seattle's Downtown Transit Tunnel and Issaquah Transit Center; Sound Transit's 554 connects to Bellevue's South Bellevue station. The nearest light rail station is at South Bellevue, with bus connections from there.
Seattle-Tacoma International Airport is about 35 miles southwest, 40 minutes by car off-peak.