Appleton is served by Appleton International Airport (ATW), with direct flights to Chicago, Minneapolis, Detroit, and a handful of other Midwest hubs. Flying into Milwaukee's Mitchell Airport and driving north on I-41 is often cheaper — about 100 miles and 90 minutes.
By road, Appleton sits on Interstate 41 in the Fox Valley corridor. Greyhound and Lamers bus services connect to Milwaukee and Green Bay. There is no Amtrak service; the nearest station with regular service is Milwaukee.