The Cathedral Basilica of Our Lady of Coromoto is the main church of Guanare, facing the central plaza. An 18th-century colonial structure with a later facade, it serves the city's Catholic community and receives a steady flow of pilgrims visiting the spiritual capital of Venezuela. The interior contains altarpieces and religious art spanning several centuries, and the atmosphere on religious feast days is intense.
The cathedral is distinct from the National Sanctuary, which is located about 55 kilometres from Guanare on the road to Agua Blanca. The sanctuary was consecrated by Pope John Paul II during his 1996 visit to Venezuela and is a large modern basilica built specifically to house the apparition site and the relic of the Virgin. Buses run from Guanare to the sanctuary, particularly on feast days when pilgrim traffic is heavy.