Sunyani is about 300km northwest of Accra, roughly 5 to 6 hours by road. Shared taxis and STC buses run regularly from Accra's Neoplan Station and from Kumasi (about 2 hours away). From Kumasi, tro-tros depart from the Kejetia terminal throughout the day. The road from Kumasi is paved and generally in good condition.
There is no rail connection to Sunyani. There is a small regional airport but scheduled commercial services are intermittent — check current availability before planning to fly.