The Cathédrale Saint-Antoine-de-Padoue stands near the centre of Ziguinchor, its white façade a landmark in the low-rise cityscape. The building blends Portuguese colonial architecture with touches of African craftsmanship — the exterior is relatively austere, but the interior holds painted panels and carved details with local motifs that give it a character distinct from the generic mission churches found elsewhere in the region.
The cathedral remains an active parish church, drawing a large congregation from the Diola Catholic community. Masses are conducted in French and Diola. The building is generally open during the day; visitors are welcome to look inside. The plaza in front serves as a quiet gathering point in the evenings.