Anantapur is on the main rail corridor between Hyderabad and Bangalore, and several express trains stop here daily. The journey from Bangalore (Krantivira Sangolli Rayanna station) takes about three hours; from Hyderabad (Secunderabad) about five hours. Anantapur railway station is a short auto-rickshaw ride from the town centre.
By road, Anantapur is on National Highway 44 (the old NH7), the main highway running the length of India from Kashmir to Kanyakumari. Regular buses connect it to Hyderabad (around 5 hours), Bangalore (3.5 hours), and regional centres including Kurnool, Kadapa, and Tirupati. The nearest airports are Puttaparthi (Sri Sathya Sai Airport, 70km) with limited flights, and Kempegowda International Airport in Bangalore (200km) with full international connections.