Machilipatnam has its own railway station (code: MTM) on the Gudivada–Machilipatnam branch line, with trains connecting to Vijayawada (around 1.5 hours). From Vijayawada you can connect to most major Indian cities by train or bus. The nearest airport is Vijayawada Airport (VGA), about 70 km away, with flights to Hyderabad, Chennai, Bangalore, and Delhi.
By road, Machilipatnam is connected to Vijayawada by state highway — the drive takes around 1.5 hours depending on traffic. APSRTC buses run frequently on this route. From Hyderabad, direct buses operate to Machilipatnam; the journey takes around 6–7 hours.