Pobitora is about 50 kilometres east of Guwahati on the south bank of the Brahmaputra. From Guwahati, the most straightforward approach is to hire a taxi or auto for the day; the journey takes around 90 minutes depending on traffic through Morigaon town. Shared vehicles run between Guwahati and Morigaon, from where local autos or cycle rickshaws can take you the final stretch to the sanctuary gate.
There is no train station at Pobitora. The nearest major rail junction is Guwahati, which is well connected to Kolkata, Delhi, and other Indian cities. Lokpriya Gopinath Bordoloi Airport in Guwahati handles domestic flights from most Indian metros; Pobitora makes an easy addition to a trip beginning or ending in Guwahati.