Khanpur Mahar sits on the main north-south road and rail corridor of the Indus plain. The N-5 national highway and the Karachi–Peshawar railway both pass close by, and trains stop at Sarhad railway station a few kilometres south. The nearest cities of any size are Ghotki and Sukkur to the south. Most travellers passing through are on their way to Punjab or down towards the Sindh coast.