Mae Sot is about 87 km west of Tak on Highway 105, a mountain road with frequent bus and minivan links. Buses also connect with Bangkok, Chiang Mai, and Sukhothai, though journeys can be long.
Mae Sot Airport has domestic service to Bangkok. The land border with Myawaddy is at the Friendship Bridge, but rules and closures can change quickly because of conditions in Myanmar. Check the current border situation before making plans that depend on crossing.