Sale sits on the Princes Highway in central Gippsland, about 210 km east of Melbourne. V/Line trains run from Melbourne's Southern Cross Station to Sale, usually with the journey taking a little over three hours.
Drivers heading through Gippsland usually reach Sale by the Princes Highway. The town is also near the South Gippsland Highway, which makes it a practical stop between the coast, the Latrobe Valley, and the Gippsland Lakes.