Orange sits on the TGV high-speed line between Paris and Marseille — direct trains from Paris Gare de Lyon take about three hours, from Marseille just over an hour. The TER regional line connects Orange to Avignon (15 minutes) and Lyon (1h45). The station is a 10-minute walk from the centre.
By car, Orange is on the A7 autoroute (exit 21) — about 30 minutes north of Avignon, an hour south of Valence. The nearest large airport is Marseille-Provence, with frequent shuttle and train connections.