Seyðisfjörður is reached by a single road — Route 93 — which climbs from Egilsstaðir over a mountain pass at around 750 metres before dropping in a series of hairpin bends to the fjord below. The drive from Egilsstaðir takes about 30 minutes and is one of the most spectacular short drives in Iceland. In winter the road is sometimes closed by snow; check the Vegagerðin road condition website (road.is) before setting out.
Egilsstaðir has the nearest airport, with daily flights from Reykjavík on Icelandair and Fly Play (check current operators). From Egilsstaðir there is a bus service to Seyðisfjörður that runs to meet the ferry — otherwise a taxi or rental car is necessary.
The Smyril Line ferry Norröna arrives once a week from Hirtshals (Denmark) via Tórshavn (Faroe Islands), typically docking on Thursdays in summer. If you are starting or finishing an Iceland trip by ferry, the schedule determines your arrival and departure days — plan accordingly, as the ferry is the most interesting way to arrive and one of the great sea crossings in the North Atlantic.