The Eucharistic Miracle of Lanciano is the town's best-known sight, preserved in the church of San Francesco. Pilgrims come to see the relics associated with the miracle, displayed in a chapel that is more intimate than grand.
For non-pilgrims, the visit is still worthwhile because it explains why Lanciano has such a religious pull. The church sits in the old centre, so it is easy to fold into a short walk between the cathedral, Santa Maria Maggiore, and the museum.