San Isidro sits on the Inter-American Highway south of San José, so buses are frequent by Costa Rican standards. The ride from the capital crosses Cerro de la Muerte and can be slow, cold, and beautiful in the same trip.
From the Pacific coast, buses and shuttles connect through Dominical and the southern zone. Travellers heading to Chirripó usually continue by local bus or taxi toward San Gerardo de Rivas.