The Museo de las Casas Reales occupies the 16th-century buildings that served as the seat of Spanish colonial governance over the Americas. The collection covers the colonial period in exhaustive detail: weapons, armour, navigational instruments, maps, documents, and everyday objects from the first century of Spanish rule in the Caribbean.
The building itself is one of the finest examples of Spanish Renaissance architecture in the Americas, with a beautiful facade on Calle de las Damas. The museum is well maintained and the collection is excellent; it provides the essential historical context for understanding everything else you will see in the Zona Colonial.