Santa María is the great volcano that watches over Quetzaltenango, a near-perfect cone rising to 3,772 metres south of the city. The climb is one of the classic highland hikes in Guatemala — demanding (you gain over 1,500 metres from the trailhead), rewarding (the view from the summit on a clear morning takes in Santiaguito's lava dome below, the Pacific coastal plain, and dozens of other volcanoes), and logistically straightforward. Most hikers set off from the village of Llanos del Pinal before dawn to be at the summit by sunrise.
The real show on a clear morning is watching Santiaguito — the active lava dome in Santa María's 1902 eruption crater — vent and occasionally explode far below. Small ash plumes rise from the dome with regularity. The dome has been erupting continuously since 1922, one of the longest-running eruptions on Earth.
Several guide agencies in Quetzaltenango run Santa María hikes; going without a guide is possible but not recommended, as the trail passes through some isolated areas.