May Pen lies on the A2 highway, roughly an hour's drive west of Kingston and 35 minutes east of Mandeville. The Toll Road (T1) bypasses the town and is the quickest option from Kingston. Buses and shared taxis to and from Kingston, Mandeville and Spanish Town are constant and inexpensive.
The nearest international airport is Norman Manley (KIN) in Kingston, about 60 km east.