The oldest building in Ciudad Juárez and one of the oldest churches in northern Mexico, the Misión de Nuestra Señora de Guadalupe was founded by Franciscan friar García de San Francisco in 1659. The thick adobe walls and the simple interior — whitewashed, with wooden beam ceilings and a carved retablo — have changed little in three and a half centuries.
It sits adjacent to the Cathedral on Plaza Principal, a short walk from the Puente Paso del Norte crossing from El Paso. Services are still held here regularly, and the mission remains an active place of worship for the local neighbourhood. The contrast between the 17th-century structure and the modern commercial chaos of the streets around it is remarkable. Entry is free; appropriate dress is expected.