Casa de la Cacica was built for the local Mixtec ruling family in the decades after the conquest. It is one of Teposcolula's most unusual buildings: part palace, part colonial house, with indigenous stonework and Spanish forms sitting awkwardly, and interestingly, together.
The building now serves as a cultural centre, so access can depend on local hours and events. Even if it is closed, the exterior helps explain Teposcolula better than a museum label would: this was a town where Mixtec authority did not simply vanish when the Dominicans arrived.