The original mission site at the top of the plaza, now occupied by the Parroquia San José church. The fourth and current church building was completed in the 1940s in Baroque Revival style, but the site has been a place of Catholic worship continuously since 1730, when Jesuit father Nicolás Tamaral established the mission among the Pericú people.
The church's interior is notable for a large mosaic mural across the entire back wall of the apse, depicting the founding of the mission and the conversion of the indigenous people. The image is striking if ideologically of its time. The mission cemetery adjacent to the church contains graves from the earliest colonial period. A small museum in the church complex presents the history of the Jesuit missions of Baja California, which were among the most remote and difficult in the Americas.