Built in 1882 by Frank Kimball and finished in time for the inaugural Santa Fe transcontinental run in 1885, the depot is a low Stick-style wooden building with deep eaves and decorative bargeboards. It is the only original transcontinental railroad terminus still standing in the United States — every other 19th-century western terminus was demolished, burned, or rebuilt.
The depot is on the National Register of Historic Places and now houses a small railway museum and the offices of the Pacific Southwest Railway Museum. Opening hours are limited; the exterior is the main draw, but the interior preserves much of the original ticket office and waiting room.