California is one of the largest states in the US and contains more variety than most countries. In a single day you can drive from Death Valley — the lowest, hottest point in North America — to the snowy peaks of the Sierra Nevada. The coastline runs 840 miles from the redwood forests of the north to the border with Mexico, passing through some of the most dramatic scenery on the continent.
Los Angeles is the dominant city in the south: sprawling, car-dependent, and endlessly diverse. Hollywood, the beaches, the food scene, and the sheer cultural weight of the place make it worth more than a quick stopover. San Diego, two hours south, is smaller and more relaxed, with excellent beaches and a compact, walkable downtown.
The San Francisco Bay Area anchors the north. San Francisco itself — hilly, foggy, and architecturally distinct — is one of the most compelling cities in the US. The Napa and Sonoma valleys start an hour north. Silicon Valley sprawls to the south along the peninsula.
Between the two metro areas, the Central Coast is the drive most people remember longest. Highway 1 through Big Sur is genuinely spectacular — sea cliffs, crashing waves, and almost no development for miles. Santa Cruz and Monterey are worth stops at either end.
Inland, the High Sierra has Yosemite and Lake Tahoe. Both are justifiably famous and worth the crowds, though you'll want to visit Yosemite Valley outside of peak summer weekends if you can manage it. The Deserts in the east — Death Valley, Joshua Tree, the Mojave — are best explored in spring or late autumn when the heat is bearable.