Wynnewood sits on US-77, the main highway running south from Oklahoma City through the Arbuckle Mountains toward Texas. From Oklahoma City it is about 70 miles south — roughly an hour's drive. The town is a logical stop if you are driving between Oklahoma City and the Arbuckle recreation areas around Davis and Sulphur.
There is no public transit serving Wynnewood. A car is essential for visiting the town and the surrounding area.