The Charles Manning Reed Mansion is a substantial Greek Revival house dating from around 1849, built for one of Erie's most prominent 19th-century citizens. It stands on West Sixth Street in the heart of Erie's historic residential district, its stuccoed exterior and Ionic columns representing the best of the Greek Revival style as it was practised in western Pennsylvania.
The mansion is listed on the National Register of Historic Places and is preserved as a historic structure. Together with the Cashier's House and Old Customshouse downtown, it forms part of the concentration of Greek Revival civic and residential architecture that gives Erie an architectural character unusual for a city of its size. The surrounding West Sixth Street area has several other 19th-century residences worth seeing on a walking tour.