Hopkins sits about 15 miles southeast of Columbia, reached most easily by car on US-378 or via Bluff Road from the city. The drive from downtown Columbia takes about 25 minutes.
There is no public transport to the park itself. Columbia Metropolitan Airport is the closest air gateway, around 35 minutes by road. If you are arriving from further afield, fly into Charlotte or Charleston and rent a car; the Lower Richland countryside is best explored with your own wheels.