The Cathedral of Our Lady of the Rosary (Catedral de Nuestra Señora del Rosario) stands on the main plaza of Cafayate, its terracotta-coloured baroque façade facing the shaded square. It is the most prominent building in town and a natural landmark for orientation. The interior is relatively simple — whitewashed walls, carved wooden altars, a few religious paintings — in the manner typical of Argentine provincial churches.
The cathedral is open most days, and the plaza in front of it is where local life happens: benches in the shade of leafy trees, children playing in the late afternoon, older residents walking in the evening. The combination of the cathedral, the surrounding historic buildings, and the view of the Calchaquí hills above the rooftops makes this one of the more attractive small-town squares in northwestern Argentina. The helado and empanada shops on the surrounding streets are excellent.