Porto Velho has flights to major Brazilian cities through Governador Jorge Teixeira de Oliveira International Airport. Long-distance buses connect it with Rio Branco, Cuiabá, BrasĂlia, and other cities, but distances in this part of Brazil are serious.
River boats run on the Madeira, including routes toward Manaus, though schedules and comfort vary. Check locally before buying a ticket and keep valuables close around the port area.