The Kasımiye Medrese stands at the western end of Mardin's old city, a 15th-century complex built by the last of the Artukid sultans. The facade, like the Sultan Isa Medrese, is elaborately carved with geometric interlacing patterns and calligraphic friezes, though the Kasımiye's style is somewhat different — heavier, more solid, reflecting a slight shift in the decorative vocabulary of the late Artukid period.
The interior has a large courtyard with a pool, two storeys of arcaded galleries, and a main prayer hall. The medrese has been carefully restored and is one of the better-maintained historic buildings in Mardin, with informational panels in Turkish and English explaining the architectural details and the Artukid dynasty. The roof terrace gives a different angle on the city and the plain below.