The Yeghegnadzor Regional Museum is a small but worthwhile stop before or after exploring the wider Vayots Dzor region. The collections include prehistoric finds from the Areni-1 cave complex (nearby is where the 6,000-year-old winery and 5,500-year-old shoe were found), as well as material from the medieval period when Vayots Dzor was an important corridor between the Armenian heartland and the south.
The museum also covers local natural history and has sections on traditional crafts and dress from the region. It's not a large institution, but for visitors wanting context on what they're seeing in the landscape — why the gorges and passes mattered, what the cave finds mean — it provides a useful framework. Labels are in Armenian and sometimes Russian; some exhibits have basic English summaries.