Sinsheim sits on the S-Bahn Rhein-Neckar S5 line. Trains run two to three times an hour from Heidelberg (around 30 minutes) and Heilbronn (around 40 minutes); both cities have ICE connections to Frankfurt, Stuttgart, and Karlsruhe. Get off at Sinsheim Museum/Arena for the Technik Museum and stadium — it is right next to the entrance. Sinsheim (Elsenz) Hbf is the stop for the town centre.
By car, take the A6 motorway (exits 33 Sinsheim or 32 Sinsheim-Süd). The museum has a huge free car park. Frankfurt Airport is around 90 minutes north; Stuttgart Airport around 60 minutes south.